The outcome of your variant on RNA or protein purpose, based on experimental proof from submitters.
This worth is calculated by NCBI according to data from submitters. Browse our regulations for calculating the overview status. The quantity of submissions which contribute to this evaluate standing is shown in parentheses.
This day signifies the final time this VCV history was updated. The update could possibly be because of an update to one of several bundled submitted records (SCVs), or because of an update that ClinVar manufactured to your variant which include introducing HGVS expressions or perhaps a rs quantity.
This column includes more info supporting the classification, like citations, the comment on classification, and in-depth evidence delivered as observations on the variant from the submitter.
The condition for that classification, provided by the submitter for this submitted (SCV) record. This column also incorporates the affected standing and allele origin of people observed using this variant.
The mixture germline classification for this variant, generally for the monogenic or Mendelian condition as from the ACMG/AMP tips, or for reaction into a drug. This value is calculated by NCBI according to details from submitters. Examine our policies for calculating the combination classification.
Study our policies for calculating the review standing. This column also features a hyperlink to your submitter’s assertion conditions if supplied, and the collection technique.
The amount of variants in ClinVar which might be contained inside of this gene, with a connection to look at the listing of variants.
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Stars symbolize the combination critique standing, or the level of evaluation supporting the aggregate germline classification for this VCV record.
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